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Psoriasis is a complex autoimmune condition with a range of contributing factors, from genetic predispositions to environmental triggers.

Psoriasis is a complex autoimmune condition affecting approximately 2% of people in the UK, according to the NHS. It is characterised by patches of red, scaly skin and can range from mild to severe.

To better understand this condition, let's delve deeper into seven potential contributing factors: incomplete protein digestion, leaky gut, abnormal liver function, bile deficiency, strep throat, nutritional deficiencies, and chronic stress.

1. Incomplete Protein Digestion

The process of protein digestion begins in the stomach, where gastric acid and enzymes break down proteins into smaller peptides. This process continues in the small intestine, where additional enzymes further break down peptides into amino acids, which are then absorbed into the bloodstream.

When this process is incomplete due to low levels of stomach acid or digestive enzymes, partially digested proteins can escape into the bloodstream. The immune system, recognizing these undigested proteins as foreign, may trigger an inflammatory response, potentially leading to or exacerbating autoimmune conditions like psoriasis. Additionally, inadequate digestion can lead to other digestive issues such as bloating, gas, and indigestion, contributing to overall inflammation in the body.

2. Leaky Gut

Leaky gut, or increased intestinal permeability, occurs when the tight junctions in the intestinal lining become compromised, allowing larger molecules, like undigested food particles, bacteria, and toxins, to pass into the bloodstream. This can trigger a systemic immune response, leading to inflammation and potentially contributing to autoimmune disorders like psoriasis.

Leaky gut is often linked to factors such as poor diet, stress, excessive alcohol consumption, and the use of certain medications like NSAIDs. When these harmful substances enter the bloodstream, they can trigger a cascade of immune reactions, potentially leading to psoriasis flare-ups or exacerbating existing symptoms. A strong connection has been observed between gut health and autoimmune conditions, suggesting that addressing gut integrity could play a role in managing psoriasis.

3. Abnormal Liver Function

The liver plays a key role in detoxifying the body, metabolizing drugs, and processing nutrients from the diet. When liver function is impaired, toxins and waste products can accumulate in the body, leading to increased inflammation and potentially contributing to psoriasis.

Liver abnormalities, such as fatty liver disease or elevated liver enzymes, have been observed in some individuals with psoriasis. The link between psoriasis and abnormal liver function may be related to the liver's role in regulating the immune system. When the liver is under stress, its ability to process toxins and produce essential compounds may be compromised, leading to a potential increase in psoriasis symptoms. Improving liver health through a balanced diet, moderate exercise, and reduced alcohol consumption may help manage psoriasis.

4. Bile Deficiency

Bile is a crucial digestive fluid produced by the liver and stored in the gallbladder. It helps emulsify fats, enabling their absorption in the small intestine. Bile also aids in the elimination of toxins from the liver.

A deficiency in bile production or secretion can lead to digestive issues, poor fat absorption (and fat soluble vitamins like A, D, E, K), and a build-up of toxins in the body. These issues can contribute to systemic inflammation, which may exacerbate psoriasis symptoms. Bile deficiency may also lead to gallstones and other digestive disorders, further complicating the management of psoriasis. Strategies to support bile production include consuming healthy fats, staying hydrated, and incorporating foods that stimulate bile production, like bitter greens and lemon juice.

5. Strep Throat

Streptococcal infections, particularly strep throat, have been associated with the onset of certain types of psoriasis, such as guttate psoriasis. The immune response to streptococcal bacteria can lead to an overactive immune reaction, with the immune system mistakenly targeting skin cells, causing psoriasis flare-ups.

In individuals with a history of strep throat, these infections can act as a trigger for psoriasis, leading to sudden outbreaks of small, red, scaly patches across the body. It's essential for individuals with psoriasis to manage strep infections promptly and effectively, as this may reduce the risk of flare-ups. Preventative measures, such as good hygiene and a healthy immune system, can help minimize the risk of streptococcal infections and, in turn, psoriasis flare-ups.

6. Nutritional Deficiencies

Nutritional deficiencies can weaken the immune system and increase the risk of autoimmune disorders like psoriasis. Deficiencies in key nutrients, such as vitamin D, zinc, selenium, omega-3 fatty acids, and antioxidants, have been linked to increased inflammation and impaired immune function.

Vitamin D, in particular, plays a significant role in skin health and immune system regulation. A deficiency in vitamin D has been associated with a higher risk of psoriasis and other autoimmune conditions. Similarly, zinc and selenium are essential for immune function, and a lack of these minerals can lead to an increased risk of inflammation and skin issues.

Omega-3 fatty acids, found in fish and flaxseed, have anti-inflammatory properties and are known to support skin health. A deficiency in these fatty acids can lead to dry, inflamed skin, potentially exacerbating psoriasis symptoms. Addressing nutritional deficiencies through a balanced diet, supplements, or medical guidance can help manage psoriasis.

7. Chronic Stress

Chronic stress is a significant factor in many autoimmune conditions, including psoriasis. Stress triggers the release of cortisol and other stress hormones, which can disrupt the body's immune and inflammatory responses. Over time, chronic stress can lead to a weakened immune system and increased inflammation, contributing to psoriasis flare-ups.

Stress can also impact lifestyle choices, leading to unhealthy eating habits, lack of exercise, and poor sleep quality—all of which can exacerbate psoriasis symptoms. Stress management techniques such as mindfulness meditation, yoga, deep breathing exercises, and regular physical activity can help reduce stress and potentially improve psoriasis symptoms. By managing stress, individuals with psoriasis can improve their overall quality of life and reduce the frequency and severity of flare-ups.

Conclusion

Psoriasis is a multifaceted condition influenced by a variety of factors.

By understanding these contributing factors and addressing them through lifestyle changes, nutritional support, and stress management, individuals with psoriasis can take proactive steps toward better managing their condition.

If you suspect that any of these factors are impacting your psoriasis, consult with a health professional like a Registered Nutritional Therapist for personalized guidance and therapy options.

Note: This article provides general information and should not be used as a substitute for professional medical advice. Consult a health provider for personalized guidance on managing psoriasis.

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